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Dear colleagues, I'm glad to present our last publication: β-Cyclodextrins as affordable antivirals to treat coronavirus infection. doi: 10.1016/j.biopha.2023.114997 I had the pleasure of being involved at the beginning of this fantastic collaborative research, discovering the antiviral activity of Hydroxypropyl beta cyclodextrin (HβCD) and U18666A against the human coronavirus 229E. Subsequently, it was shown that both compounds showed in vitro antiviral activity also against SARS-CoV-2. Finally, β-cyclodextrins prevented infection in human nasal epithelium ex vivo and, in hamster in vivo models showing a prophylactic effect. These results and the high safety profile in humans of β-cyclodextrins support their clinical testing as prophylactic antivirals.#research #cyclodextrins #antivirals #SarsCoV2 #safety #testing
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Tom Uil
Teacher Chemistry
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Interesting. SARS-CoV-2 can use an alternative entry receptor.
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Scientific Research Publishing
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【Glycyrrhizic Acid-Loaded Poly-ɛ-Caprolactone Nanoparticles Decrease PRRSV Infection in MARC-145 Cells】Full article: https://lnkd.in/gER75FDV (Authored by Samantha Jardon, et al., from UNAM-FESC (Mexico), etc.)Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating disease with worldwide distribution caused by Betaarterivirus suid (#PRRSV). The causative agent Betaarterivirus suid (PRRSV) shows great genetic and antigenic variability with a marked increase in virulence. This study evaluates the in vitro effect of the antiviral content in poly-ε-caprolactone nanoparticles containing #glycyrrhizic_acid (PNPsGA) as a new therapeutic strategy for treating PRRSV infections. #Cytotoxicity #Cell_Morphology #Polymeric_Nanoparticles
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Credo Diagnostics Biomedical
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The seasonal cycle of respiratory viral diseases is still ongoing, and you may have encountered the recent high alert regarding the SARS-CoV-2 variant, BA.2.86. This new variant carries an additional 34 mutations in the spike protein, giving it a significant evolutionary advantage in evading immune responses.In the latest COVID-19 data update from the Centers for Disease Control and Prevention* [1], BA.2.86. are continually being detected sporadically in various countries and has been identified in additional countries from both human and wastewater specimens. It has also caused an outbreak at a nursing home in the UK* [2], with data pointing to an alarming 86.6% attack rate among residents. The concern is that “it may be sufficiently transmissible to have an impact in certain settings, including nursing homes.”At Credo Diagnostics Biomedical, we remain committed to post-market monitoring so as to ensure the reliability of our assay. Our VitaPCR™ system is capable of detecting the variant BA.2.86, and our analysis has confirmed that the performance of our SARS-CoV-2 RNA detection assays is not impacted by BA.2.86. For more information, contact us at service@credodxbiomed.com.View the statement here: https://lnkd.in/gqP5SMTZ*Sources:[1] https://lnkd.in/epYdQ2CD[2] https://lnkd.in/ga7KVZRq#CredoDiagnostics #VitaPCR #Variant #ba286 #COVID
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Phys.org
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Vaccinia viruses are therapeutic tools with different biomedical applications depending on the susceptibility characteristics.
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BiCT srl - Biological and Chemical Technologies
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👉 Against Herpes 👈Antiviral activity was evaluated using Cf2Th cells infected with herpes virus CHV-1.In particular, the cell lysis generated by co-incubation with the virus and the compound of interest was assessed, using incubation with virus alone as a reference. Lactive® was demonstrated able to inhibit virus infection and proliferation already at a concentration of 3%, being able to preserve the cells intact from infection.Find out more, Contact us!customerservice_italy@bict.itGIFFORD JL, Hunter HN, Vogel HJ. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cellular and Molecular Life Sciences : CMLS. 2005, 62(22):2588-2598.SHESTAKOV, Andrey, et al. Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice. Antiviral research, 2012, 93.3: 340-345.#lactive #lactoferricin #naturalhealt #naturalpeptide #boostyourproduct #lactoferrin #innovation #biotech #medicaldevice #ingredienteattivo #lattoferricina #antivirale #antibatterico #immunostimolante #microbioma https://lnkd.in/evVgM4KM
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BiCT srl - Biological and Chemical Technologies
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👉 Against Herpes 👈Antiviral activity was evaluated using Cf2Th cells infected with herpes virus CHV-1.In particular, the cell lysis generated by co-incubation with the virus and the compound of interest was assessed, using incubation with virus alone as a reference. Lactive® was demonstrated able to inhibit virus infection and proliferation already at a concentration of 3%, being able to preserve the cells intact from infection.Find out more, Contact us!customerservice_italy@bict.itGIFFORD JL, Hunter HN, Vogel HJ. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cellular and Molecular Life Sciences : CMLS. 2005, 62(22):2588-2598.SHESTAKOV, Andrey, et al. Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice. Antiviral research, 2012, 93.3: 340-345.#lactive #lactoferricin #naturalhealt #naturalpeptide #boostyourproduct #lactoferrin #innovation #biotech #medicaldevice #ingredienteattivo #lattoferricina #antivirale #antibatterico #immunostimolante #microbioma https://lnkd.in/evVgM4KM
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BiCT srl - Biological and Chemical Technologies
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👉 Against Herpes 👈Antiviral activity was evaluated using Cf2Th cells infected with herpes virus CHV-1.In particular, the cell lysis generated by co-incubation with the virus and the compound of interest was assessed, using incubation with virus alone as a reference. Lactive® was demonstrated able to inhibit virus infection and proliferation already at a concentration of 3%, being able to preserve the cells intact from infection.Find out more, Contact us!customerservice_italy@bict.itGIFFORD JL, Hunter HN, Vogel HJ. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cellular and Molecular Life Sciences : CMLS. 2005, 62(22):2588-2598.SHESTAKOV, Andrey, et al. Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice. Antiviral research, 2012, 93.3: 340-345.#lactive #lactoferricin #naturalhealt #naturalpeptide #boostyourproduct #lactoferrin #innovation #biotech #medicaldevice #ingredienteattivo #lattoferricina #antivirale #antibatterico #immunostimolante #microbioma https://lnkd.in/evVgM4KM
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Silvia Rapacioli
President and M&S Head at BiCT srl
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👉 Against Herpes 👈Antiviral activity was evaluated using Cf2Th cells infected with herpes virus CHV-1.In particular, the cell lysis generated by co-incubation with the virus and the compound of interest was assessed, using incubation with virus alone as a reference. Lactive® was demonstrated able to inhibit virus infection and proliferation already at a concentration of 3%, being able to preserve the cells intact from infection.Find out more, Contact us!customerservice_italy@bict.itGIFFORD JL, Hunter HN, Vogel HJ. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cellular and Molecular Life Sciences : CMLS. 2005, 62(22):2588-2598.SHESTAKOV, Andrey, et al. Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice. Antiviral research, 2012, 93.3: 340-345.#lactive #lactoferricin #naturalhealt #naturalpeptide #boostyourproduct #lactoferrin #innovation #biotech #medicaldevice #ingredienteattivo #lattoferricina #antivirale #antibatterico #immunostimolante #microbioma https://lnkd.in/er3Zh3P6
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Silvia Rapacioli
President and M&S Head at BiCT srl
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👉 Against Herpes 👈Antiviral activity was evaluated using Cf2Th cells infected with herpes virus CHV-1.In particular, the cell lysis generated by co-incubation with the virus and the compound of interest was assessed, using incubation with virus alone as a reference. Lactive® was demonstrated able to inhibit virus infection and proliferation already at a concentration of 3%, being able to preserve the cells intact from infection.Find out more, Contact us!customerservice_italy@bict.itGIFFORD JL, Hunter HN, Vogel HJ. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cellular and Molecular Life Sciences : CMLS. 2005, 62(22):2588-2598.SHESTAKOV, Andrey, et al. Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice. Antiviral research, 2012, 93.3: 340-345.#lactive #lactoferricin #naturalhealt #naturalpeptide #boostyourproduct #lactoferrin #innovation #biotech #medicaldevice #ingredienteattivo #lattoferricina #antivirale #antibatterico #immunostimolante #microbioma https://lnkd.in/er3Zh3P6
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