Paula Ortega González, PhD on LinkedIn: #research #cyclodextrins #antivirals #sarscov2 #safety #testing (2024)

Paula Ortega González, PhD

R&D Scientist | Project Manager | Cell Biology | Virology

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Dear colleagues, I'm glad to present our last publication: β-Cyclodextrins as affordable antivirals to treat coronavirus infection. doi: 10.1016/j.biopha.2023.114997 I had the pleasure of being involved at the beginning of this fantastic collaborative research, discovering the antiviral activity of Hydroxypropyl beta cyclodextrin (HβCD) and U18666A against the human coronavirus 229E. Subsequently, it was shown that both compounds showed in vitro antiviral activity also against SARS-CoV-2. Finally, β-cyclodextrins prevented infection in human nasal epithelium ex vivo and, in hamster in vivo models showing a prophylactic effect. These results and the high safety profile in humans of β-cyclodextrins support their clinical testing as prophylactic antivirals.#research #cyclodextrins #antivirals #SarsCoV2 #safety #testing

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Paula Ortega González, PhD on LinkedIn: #research #cyclodextrins #antivirals #sarscov2 #safety #testing (2024)
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